Hosta

by | Mar 16, 2018 | Hosta

How Can We Help?
You are here:
< Back

BD1060 or N-[2-(3,4-dichlorophenyl)ethyl]-1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of Ki = 3 ± 0.1 nM for the sigma-1 receptor and greater than 50 times selectivity over the sigma-2 receptor.[1]

Like other sigma receptor antagonists, pretreating Swiss Webster mice with BD1060 significantly reduces the behavioral toxicity of cocaine.[1]

See also

References

  1. ^ a b Matsumoto RR, McCracken KA, Pouw B, Miller J, Bowen WD, Williams W, De Costa BR (2001). "N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice". Eur. J. Pharmacol. 411 (3): 261–73. doi:10.1016/s0014-2999(00)00917-1.
Categories
Table of Contents