α-Zearalenol is a nonsteroidal estrogen of the resorcylic acid lactone group related to mycoestrogens found in Fusarium spp.[1] It is the α-epimer of β-zearalenol.[2] Along with β-zearalenol, it is a major metabolite of zearalenone formed mainly in the liver but also to a lesser extent in the intestines during first-pass metabolism.[2][3] A relatively low proportion of β-zearalenol is metabolized from zearalenone compared to α-zearalenol in humans.[3] α-Zearalenol is about three to four times more potent as an estrogen relative to zearalenone.[1]

See also

References

  1. ^ a b Chelkowski J (28 June 2014). Fusarium: Mycotoxins, Taxonomy, Pathogenicity. Elsevier Science. pp. 85–. ISBN 978-1-4832-9785-9.
  2. ^ a b Magan N, Olsen M (2004). Mycotoxins in Food: Detection and Control. Woodhead Publishing. pp. 356–. ISBN 978-1-85573-733-4.
  3. ^ a b Eriksen GS (1998). Fusarium Toxins in Cereals: A Risk Assessment. Nordic Council of Ministers. pp. 61–. ISBN 978-92-893-0149-7.