Hosta

For beta-glucuronidase, see Beta-glucuronidase

In enzymology, an alpha-glucuronidase (EC 3.2.1.139) is an enzyme that catalyzes the chemical reaction

an alpha-D-glucuronoside + H₂O an alcohol + D-glucuronate

Thus, the two substrates of this enzyme are alpha-D-glucuronoside and H₂O, whereas its two products are alcohol and D-glucuronate.

This enzyme belongs to the family of hydrolases, to be specific those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is alpha-D-glucosiduronate glucuronohydrolase. This enzyme is also called alpha-glucosiduronase.

Structural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1GQI, 1GQJ, 1GQK, 1GQL, 1H41, 1K9D, 1K9E, 1K9F, 1L8N, 1MQP, 1MQQ, 1MQR, and 1VJT.

See also

• Beta-glucuronidase
• Glucuronosyl-disulfoglucosamine glucuronidase
• Glycyrrhizinate beta-glucuronidase

References

• Visser, J., Kusters van Someren, M.A., Beldman, G. and Voragen, A.G.J. (Eds.), Xylans and Xylanases, Elsevier, Amsterdam, 1992, p. 213-224.
• Uchida H, Nanri T, Kawabata Y, Kusakabe I, Murakami K (1992). "Purification and characterization of intracellular alpha-glucuronidase from Aspergillus niger". Biosci. Biotechnol. Biochem. 56 (10): 1608–1615. doi:10.1271/bbb.56.1608.