Acotiamide, sold under the brand name Acofide,[2][3] is a medication manufactured and approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia.[4] It acts as an acetylcholinesterase inhibitor.

References

  1. ^ "Acofide (acotiamide hydrochloride hydrate) Tablets Review Report" (PDF). Retrieved 29 December 2016.
  2. ^ Nowlan ML, Scott LJ (August 2013). "Acotiamide: first global approval". Drugs. 73 (12): 1377–83. doi:10.1007/s40265-013-0100-9. PMID 23881665. S2CID 20383853.
  3. ^ Matsunaga Y, Tanaka T, Saito Y, Kato H, Takei M (February 2014). "[Pharmacological and clinical profile of acotiamide hydrochloride hydrate (Acofide(®) Tablets 100 mg), a novel therapeutic agent for functional dyspepsia (FD)]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 143 (2): 84–94. doi:10.1254/fpj.143.84. PMID 24531902.
  4. ^ Matsueda K, Hongo M, Tack J, Aoki H, Saito Y, Kato H (June 2010). "Clinical trial: dose-dependent therapeutic efficacy of acotiamide hydrochloride (Z-338) in patients with functional dyspepsia - 100 mg t.i.d. is an optimal dosage". Neurogastroenterology and Motility. 22 (6): 618–e173. doi:10.1111/j.1365-2982.2009.01449.x. PMID 20059698. S2CID 41298446.