4'-Hydroxyflavanone is a naturally occurring monohydroxybenzoic acid and a member of the 4'-hydroxyflavanones family. It is white to pale orange in color and generally soluble in organic solvents such as chloroform and ethanol, but insoluble with water.[2] 4'-Hydroxyflavanone is a naturally occurring product with cosmetic and potential clinical applications that is found in plants such as carnations (Dianthus caryophyllus).

Natural occurrence

As part of the flavanone family, 4'-hydroxyflavanone can be found naturally in celery, red peppers, citrus fruits, parsley (Petroselinum crispum), berries, tea, and onions (Allium cepa L.).[3]

Applications

Cosmetic

Flavanone, with its orange-like color, has been used in natural dyes for cotton fabrics.[4] Additionally, flavanone is used in various anti-wrinkle cosmetics and skin care products to treat psoriasis, melanogenesis, and photo-aging.[5]

Clinical research

4'-Hydroxyflavanone is an inhibitor of SREBP, transcription factors that control the expression of a range of enzymes that regulate lipid homeostasis.[6]

Research also suggests that 4'-hydroxyflavanones have potential pharmaceutic applications against fatty liver disease, hepatic steatosis, and dyslipidemia.[6]

Flavanones are widely considered to be beneficial to human health as a result of their ability to control free radicals in the body. Flavanones deriving from citrus fruits in particular exhibit antioxidant, anti-inflammatory, blood lipid-lowering and cholesterol-lowering agents.[3]

In general, flavonoids have been used extensively as anticancer, antimicrobial, antiviral, antiangiogenic, antimalarial, antioxidant, neuroprotective, antitumor, and anti-proliferative agents.[4] Extracts that were rich in flavonoids have also been demonstrated to be ACE inhibitors in vitro, therefore acting as effective antihypertensive agents. They also have been shown to prevent cardio-metabolic disorders and preserve cognitive performance with aging.[4]

Toxicity

4'-Hydroxyflavanone is classified as an irritant due to its ability to cause skin corrosion, eye damage, and respiratory tract irritation if unprotected exposure occurs.[7]

References

  1. ^ "4'-Hydroxyflavanone". pubchem.ncbi.nlm.nih.gov.
  2. ^ Miao L, Zhang H, Yang L, Chen L, Xie Y, Xiao J (2020). "Flavonoids". In Nabavi SM, Silva AS (eds.). Antioxidants effects in health: the bright and the dark side. Amsterdam: Elsevier. pp. 353–374. doi:10.1016/B978-0-12-819096-8.00048-3. ISBN 978-0-12-819096-8.
  3. ^ a b Panche AN, Diwan AD, Chandra SR (2016). "Flavonoids: an overview". Journal of Nutritional Science. 5: e47. doi:10.1017/jns.2016.41. PMC 5465813. PMID 28620474.
  4. ^ a b c Ullah A, Munir S, Badshah SL, Khan N, Ghani L, Poulson BG, et al. (November 2020). "Important Flavonoids and Their Role as a Therapeutic Agent". Molecules. 25 (22): 5243. doi:10.3390/molecules25225243. PMC 7697716. PMID 33187049.
  5. ^ Alalaiwe A, Lin CF, Hsiao CY, Chen EL, Lin CY, Lien WC, et al. (May 2020). "Development of flavanone and its derivatives as topical agents against psoriasis: The prediction of therapeutic efficiency through skin permeation evaluation and cell-based assay". International Journal of Pharmaceutics. 581: 119256. doi:10.1016/j.ijpharm.2020.119256. PMID 32220586.
  6. ^ a b "4'-Hydroxyflavanone". NCATS Inxight Drugs. National Center for Advancing Translational Sciences (NCATS), U.S. Food and Drug Administration. Retrieved 2024-04-10.
  7. ^ "4'-Hydroxyflavanone". PubChem. National Center for Biotechnology Information (NCBI), U.S. National Library of Medicine. Retrieved 2024-04-10.