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by | Mar 16, 2018 | Hosta

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Not to be confused with Dextrorphan, Dextromethorphan, or Levomethorphan.

3-Methoxymorphinan is an inactive metabolite of both dextromethorphan and levomethorphan, and has been shown to produce local anesthetic effects.[1] It is the CYP3A4 metabolite of the aforementioned druges,[2] and is itself metabolized by the liver enzyme CYP2D6.[3]

See also

References

  1. ^ Hou CH, Tzeng JI, Chen YW, Lin CN, Lin MT, Tu CH, Wang JJ (August 2006). "Dextromethorphan, 3-methoxymorphinan, and dextrorphan have local anaesthetic effect on sciatic nerve blockade in rats". European Journal of Pharmacology. 544 (1–3): 10–16. doi:10.1016/j.ejphar.2006.06.013. PMID 16844109.
  2. ^ Min DI, Ku YM, Vichiendilokkul A, Fleckenstein LL (June 1999). "A urine metabolic ratio of dextromethorphan and 3-methoxymorphinan as a probe for CYP3A activity and prediction of cyclosporine clearance in healthy volunteers". Pharmacotherapy. 19 (6): 753–759. doi:10.1592/phco.19.9.753.31536. PMID 10391422. S2CID 32243163.
  3. ^ Strauch K, Lutz U, Bittner N, Lutz WK (August 2009). "Dose-response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles". Food and Chemical Toxicology. 47 (8): 1928–1935. doi:10.1016/j.fct.2009.05.004. PMID 19445995.
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