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Chemical compound, GABA(B) receptor antagonist
Chemical compound
2-Hydroxysaclofen is a GABAB receptor antagonist and an analogue of saclofen.
Pharmacodynamics
2-Hydroxysaclofen binds to the GABAB receptor, but this is selective for the (S)-enantiomer, while the (R)-enantiomer does not bind to the GABAB protein.[1]
2-Hydroxysaclofen has been reported to be more potent than saclofen.[2]
See also
- Saclofen - another GABAB receptor antagonist
- Baclofen - an agonist of the receptor
References
- ^ "2 Hydroxysaclofen - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2024-02-03.
- ^ "2-Hydroxysaclofen".
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