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Chemical compound
16-Ketoestrone (16-keto-E1, or 16-oxoestrone, or 16-oxo-E1) is an endogenous estrogen related to 16α-hydroxyestrone and 16β-hydroxyestrone.[1][2][3] In contrast to 16α-hydroxyestrone and 16β-hydroxyestrone, but similarly to 16-ketoestradiol, 16-ketoestrone is a very weak estrogen with less than 1/1000 the estrogenic potency of estrone in the uterus.[3] 16-Ketoestrone has been reported to act as an inhibitor of 17β-hydroxysteroid dehydrogenases.[4] 16-Ketoestrone can be converted by 16α-hydroxysteroid dehydrogenase into estriol in the body.[1][5]
References
- ^ a b Breuer, Heinz (1962). "The Metabolism of the Natural Estrogens". Vitamins & Hormones. 20: 285–335. doi:10.1016/S0083-6729(08)60720-7. ISBN 9780127098203. ISSN 0083-6729.
- ^ Huffman MN, Lott MH (January 1948). "16-Substituted steroids; 16-keto-alpha-estradiol and 16-ketoestrone". J. Biol. Chem. 172 (1): 325–32. doi:10.1016/S0021-9258(18)35637-0. PMID 18920793.
- ^ a b Huggins C, Jensen EV (September 1955). "The depression of estrone-induced uterine growth by phenolic estrogens with oxygenated functions at positions 6 or 16: the impeded estrogens". J. Exp. Med. 102 (3): 335–46. doi:10.1084/jem.102.3.335. PMC 2136510. PMID 13252187.
- ^ Inano H, Tamaoki B (January 1983). "Affinity labeling of arginyl residues at the catalytic region of estradiol 17 beta-dehydrogenase from human placenta by 16-oxoestrone". Eur. J. Biochem. 129 (3): 691–5. doi:10.1111/j.1432-1033.1983.tb07104.x. PMID 6572146.
- ^ Stimmel BF, Grollman A, Huffman MN (June 1950). "The metabolism of 16-ketoestrone and 16-keto-estradiol in man". J. Biol. Chem. 184 (2): 677–85. doi:10.1016/S0021-9258(19)51001-8. PMID 15428451.
ERTooltip Estrogen receptor |
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GPERTooltip G protein-coupled estrogen receptor |
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