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11β-Hydroxyandrostenedione (11β-OHA4), also known as 11β-hydroxyandrost-4-ene-3,17-dione, is an endogenous, naturally occurring steroid and androgen prohormone that is produced primarily, if not exclusively, in the adrenal glands.^[1] It is closely related to adrenosterone (11-ketoandrostenedione; 11-KA4), 11-ketotestosterone (11-KT), and 11-ketodihydrotestosterone (11-KDHT), which are also produced in the adrenal glands.^[1]

It can be used as a biomarker for guiding primary aldosteronism subtyping in adrenal vein sampling where blood samples are taken from both adrenal glands to compare the amount of hormone made by each gland.^[2]

References

^ ^a ^b Pretorius, Elzette; Arlt, Wiebke; Storbeck, Karl-Heinz (2016). "A new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids" (PDF). Molecular and Cellular Endocrinology. 441: 76–85. doi:10.1016/j.mce.2016.08.014. ISSN 0303-7207. PMID 27519632. S2CID 4079662.
^ Turcu, A. F.; Wannachalee, T.; Tsodikov, A.; Nanba, A. T.; Ren, J.; Shields, J. J.; O'Day, P. J.; Giacherio, D.; Rainey, W. E.; Auchus, R. J. (2020). "Comprehensive Analysis of Steroid Biomarkers for Guiding Primary Aldosteronism Subtyping". Hypertension. 75 (1): 183–192. doi:10.1161/HYPERTENSIONAHA.119.13866. PMC 7034384. PMID 31786984.

[pmid27519632-1] Pretorius, Elzette; Arlt, Wiebke; Storbeck, Karl-Heinz (2016). "A new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids" (PDF). Molecular and Cellular Endocrinology. 441: 76–85. doi:10.1016/j.mce.2016.08.014. ISSN 0303-7207. PMID 27519632. S2CID 4079662.

[pmid31786984-2] Turcu, A. F.; Wannachalee, T.; Tsodikov, A.; Nanba, A. T.; Ren, J.; Shields, J. J.; O'Day, P. J.; Giacherio, D.; Rainey, W. E.; Auchus, R. J. (2020). "Comprehensive Analysis of Steroid Biomarkers for Guiding Primary Aldosteronism Subtyping". Hypertension. 75 (1): 183–192. doi:10.1161/HYPERTENSIONAHA.119.13866. PMC 7034384. PMID 31786984.

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[2]

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See also

References

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