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by | Mar 16, 2018 | Hosta

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1-Methylcytosine is a methylated form of the DNA base cytosine.

In 1-methylcytosine, a methyl group is attached to the 1st atom in the 6-atom ring. This methyl group distinguishes 1-methylcytosine from cytosine.

History

Miriam Rossi worked on the refinement of 1-methylcytosine.[1]

1-Methylcytosine is used as a nucleobase of hachimoji DNA, in which it pairs with isoguanine.[2]

References

  1. ^ Kistenmacher, T. J.; Rossi, M. (1977-12-15). "1-Methylcytosine: a refinement". Acta Crystallographica Section B. 33 (12): 3962–3965. Bibcode:1977AcCrB..33.3962R. doi:10.1107/S0567740877012618. ISSN 0567-7408.
  2. ^ Hoshika, Shuichi; et al. (22 February 2019). "Hachimoji DNA and RNA: A genetic system with eight building blocks". Science. 363 (6429): 884–887. Bibcode:2019Sci...363..884H. doi:10.1126/science.aat0971. PMC 6413494. PMID 30792304.
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