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Chemical compound
PHTPP is a synthetic, nonsteroidal, and highly selective antagonist of ERβ that is used in scientific research to study the function of this receptor.[1][2] It possesses 36-fold selectivity for ERβ over ERα, and is a silent antagonist of ERβ.[3]
See also
- Propylpyrazoletriol (PPT)
- Methylpiperidinopyrazole (MPP)
- (R,R)-Tetrahydrochrysene ((R,R)-THC)
- Diarylpropionitrile (DPN)
- Prinaberel (ERB-041)
- Liquiritigenin
- Menerba
- WAY-200070
References
- ^ Neurosteroids. Frontiers E-books. pp. 95–. ISBN 978-2-88919-078-2.
- ^ Cytoplasmic and Nuclear Receptors—Advances in Research and Application: 2012 Edition. ScholarlyEditions. 26 December 2012. pp. 220–. ISBN 978-1-4649-9741-9.
- ^ Compton DR, Sheng S, Carlson KE, Rebacz NA, Lee IY, Katzenellenbogen BS, Katzenellenbogen JA (November 2004). "Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity". Journal of Medicinal Chemistry. 47 (24): 5872–93. doi:10.1021/jm049631k. PMID 15537344.
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