How Can We Help?
You are here:
< Back

The aortic sac or aortic bulb[1] is a dilated structure in mammalian embryos, lined by endothelial cells and is the most distal part of the truncus arteriosus.[2] It is the primordial vascular channel from which the aortic arches arise (and eventually the dorsal aortae) and is homologous to the ventral aorta of gill-bearing vertebrates. The aortic sac eventually forms right and left horns, which subsequently give rise to the brachiocephalic trunk and the proximal segment of the arch of aorta, respectively.[2]

Genes HAND2 (dHAND) and HAND1 (eHAND) are expressed during the development of the aortic bulb and the arteries which arise from it.[3] The protein encoded by these genes belong to the basic helix-loop-helix family of transcription factors.

References

  1. ^ Annalisa Berta, James L. Sumich, Kit M. Kovacs. Marine Mammals: Evolutionary Biology. Academic Press, 2006; page 240.
  2. ^ a b Sadler, T. W. (2019). Langman's Medical Embryology (14th ed.). Philadelphia. p. 206. ISBN 978-1-4963-8390-7. OCLC 1042400100.{{cite book}}: CS1 maint: location missing publisher (link)
  3. ^ Richard P. Harvey, Nadia Rosenthal (ed). Heart Development. Gulf Professional Publishing, 1999; page 150-151.


Categories
Table of Contents