Galanthus

by | Mar 18, 2018 | Galanthus

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Satavaptan (INN; developmental code name SR121463, former tentative brand name Aquilda) is a vasopressin-2 receptor antagonist[1] which was investigation by Sanofi-Aventis and was under development for the treatment of hyponatremia. It was also being studied for the treatment of ascites.[2] Development was discontinued in 2009.[3]

References

  1. ^ Soupart A, Gross P, Legros JJ, Alföldi S, Annane D, Heshmati HM, Decaux G (November 2006). "Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist". Clinical Journal of the American Society of Nephrology. 1 (6): 1154–60. doi:10.2215/CJN.00160106. PMID 17699341.
  2. ^ Ginès P, Wong F, Watson H, Milutinovic S, del Arbol LR, Olteanu D (July 2008). "Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trial". Hepatology. 48 (1): 204–13. doi:10.1002/hep.22293. PMID 18508290.
  3. ^ "Satavaptan". Adis Insight. Springer Nature Switzerland AG.
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