Flowering Dogwood – Cornus florida

by | Dec 14, 2023 | NE Native Trees

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Epi-isozizaene 5-monooxygenase (EC 1.14.13.106, CYP170A1) is an enzyme with systematic name (+)-epi-isozizaene,NADPH:oxygen oxidoreductase (5-hydroxylating).[1] This enzyme catalyses the following chemical reaction

(+)-epi-isozizaene + 2 NADPH + 2 H+ + 2 O2 albaflavenone + 2 NADP+ + 3 H2O (overall reaction)
(1a) (+)-epi-isozizaene + NADPH + H+ + O2 (5S)-albaflavenol + NADP+ + H2O
(1b) (5S)-albaflavenol + NADPH + H+ + O2 albaflavenone + NADP+ + 2 H2O
(2a) (+)-epi-isozizaene + NADPH + H+ + O2 (5R)-albaflavenol + NADP+ + H2O
(2b) (5R)-albaflavenol + NADPH + H+ + O2 albaflavenone + NADP+ + 2 H2O

This cytochrome P450 enzyme is purified from bacterium Streptomyces coelicolor.

References

  1. ^ Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE (March 2008). "Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2)". The Journal of Biological Chemistry. 283 (13): 8183–9. doi:10.1074/jbc.M710421200. PMC 2276382. PMID 18234666.

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