Flame Azalea – Rhododendron calendulaceum

In enzymology, an oxalate—CoA ligase (EC 6.2.1.8) is an enzyme that catalyzes the chemical reaction

ATP + oxalate + CoA

\rightleftharpoons

AMP + diphosphate + oxalyl-CoA

The 3 substrates of this enzyme are ATP, oxalate, and coenzyme A (CoA), whereas its 3 products are AMP, diphosphate, and oxalyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is oxalate:CoA ligase (AMP-forming). Other names in common use include oxalyl-CoA synthetase, and oxalyl coenzyme A synthetase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Organisms with Oxalate-CoA Ligases include:
Arabidopsis thaliana^[1]
Saccharomyces cerevisiae^[2]

References

^ "A Previously Unknown Oxalyl-CoA Synthetase Is Important for Oxalate Catabolism in Arabidopsis". www.plantcell.org. Archived from the original on 24 September 2015. Retrieved 17 September 2023.
^ Foster J, Nakata PA (2014). "An oxalyl-CoA synthetase is important for oxalate metabolism in Saccharomyces cerevisiae". FEBS Lett. 588 (1): 160–6. doi:10.1016/j.febslet.2013.11.026. PMID 24291261.

Giovanelli J (1966). "Oxalyl-coenzyme A synthetase from pea seeds". Biochim. Biophys. Acta. 118 (1): 124–43. doi:10.1016/s0926-6593(66)80151-0. PMID 4288975.

[1] "A Previously Unknown Oxalyl-CoA Synthetase Is Important for Oxalate Catabolism in Arabidopsis". www.plantcell.org. Archived from the original on 24 September 2015. Retrieved 17 September 2023.

[2] Foster J, Nakata PA (2014). "An oxalyl-CoA synthetase is important for oxalate metabolism in Saccharomyces cerevisiae". FEBS Lett. 588 (1): 160–6. doi:10.1016/j.febslet.2013.11.026. PMID 24291261.

[1]

[2]

Enzymes: CO CS and CN ligases (EC 6.1-6.3)
6.1: Carbon-Oxygen	Aminoacyl tRNA synthetase Alanine Arginine Asparagine Aspartate Cysteine D-alanine—poly(phosphoribitol) ligase Glutamate Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine
6.2: Carbon-Sulfur	Succinyl coenzyme A synthetase Acetyl—CoA synthetase Long-chain-fatty-acid—CoA ligase
6.3: Carbon-Nitrogen	Glutamine synthetase Ubiquitin ligase Cullin Von Hippel–Lindau tumor suppressor UBE3A Mdm2 Anaphase-promoting complex UBR1 Glutathione synthetase CTP synthetase Adenylosuccinate synthase Argininosuccinate synthase Holocarboxylase synthetase GMP synthase Asparagine synthetase Carbamoyl phosphate synthetase I II Glutamate–cysteine ligase

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Flame Azalea – Rhododendron calendulaceum

References

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