Fatsia Japonica

by | Mar 19, 2018 | Fatsia_japonica

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AC927 or 1-(2-phenylethyl)piperidine is a selective sigma receptor antagonist, with reported binding affinity of Ki = 30 ± 2 nM for the sigma-1 receptor and Ki = 138 ± 18 nM for the sigma-2 receptor, and negligible binding affinity for other major central nervous system receptors, transporters, and ion channels.[1]

AC927 is reported to attenuate the locomotor stimulation induced by methamphetamine in mice.[1]

References

  1. ^ a b Matsumoto RR, Shaikh J, Wilson LL, Vedam S, Coop A (2008). "Attenuation of methamphetamine-induced effects through the antagonism of sigma (σ) receptors: Evidence from in vivo and in vitro studies". Eur. Neuropsychopharmacol. 18 (12): 871–81. doi:10.1016/j.euroneuro.2008.07.006. PMC 2688716. PMID 18755577.
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