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In molecular biology mir-25 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir-25 levels increase in human heart failure, and treatment with an anti-sense RNA molecule (antagomiR) was recently reported to halt disease progression and improves cardiac function in a mouse heart failure model.[1]
See also
References
- ^ Wahlquist C, Jeong D, Rojas-Muñoz A, Kho C, Lee A, Mitsuyama S, van Mil A, Park WJ, Sluijter JP, Doevendans PA, Hajjar RJ, Mercola M (April 2014). "Inhibition of miR-25 improves cardiac contractility in the failing heart". Nature. 508 (7497): 531–5. doi:10.1038/nature13073. PMC 4131725. PMID 24670661.
Further reading
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- Fu Y, Zhang Y, Wang Z, Wang L, Wei X, Zhang B, Wen Z, Fang H, Pang Q, Yi F (2010). "Regulation of NADPH oxidase activity is associated with miRNA-25-mediated NOX4 expression in experimental diabetic nephropathy". American Journal of Nephrology. 32 (6): 581–9. doi:10.1159/000322105. PMID 21071935. S2CID 31810215.
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