Cimicifuga

by | Mar 12, 2018 | Cohosh

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Not to be confused with androstanediol, androstenedione, androstenediol, or androstadienol.

Androstanedione, also known as 5α-androstanedione or as 5α-androstane-3,17-dione, is a naturally occurring androstane (5α-androstane) steroid and an endogenous metabolite of androgens like testosterone, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), and androstenedione.[1] It is the C5 epimer of etiocholanedione (5β-androstanedione).[1] Androstanedione is formed from androstenedione by 5α-reductase and from DHT by 17β-hydroxysteroid dehydrogenase.[2][3] It has some androgenic activity.[4]

In female genital skin, the conversion of androstenedione into DHT through 5α-androstanedione appears to be more important than the direct conversion of testosterone into DHT.[5]

References

  1. ^ a b "Human Metabolome Database: Showing metabocard for Androstanedione (HMDB0000899)".
  2. ^ Kenneth L. Becker (2001). Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins. pp. 994–. ISBN 978-0-7817-1750-2.
  3. ^ Eric S. Orwoll; John P. Bilezikian; Dirk Vanderschueren (30 November 2009). Osteoporosis in Men: The Effects of Gender on Skeletal Health. Academic Press. pp. 296–. ISBN 978-0-08-092346-8.
  4. ^ Charles D. Kochakian (6 December 2012). Anabolic-Androgenic Steroids. Springer Science & Business Media. pp. 171–. ISBN 978-3-642-66353-6.
  5. ^ Stanczyk FZ (June 2006). "Diagnosis of hyperandrogenism: biochemical criteria". Best Pract Res Clin Endocrinol Metab. 20 (2): 177–91. doi:10.1016/j.beem.2006.03.007. PMID 16772150.

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