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Chemical compound
Tybamate (INN; Solacen, Tybatran, Effisax) is an anxiolytic of the carbamate family.[1] It is a prodrug for meprobamate in the same way as the better known drug carisoprodol. It has liver enzyme inducing effects similar to those of phenobarbital but much weaker.[2]
As the trade name Tybatran (Robins), it was formerly available in capsules of 125, 250, and 350 mg, taken 3 or 4 times a day for a total daily dosage of 750 mg to 2 g. The plasma half-life of the drug is three hours. At high doses in combination with phenothiazines, it could produce convulsions.[3]
References
- ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. p. 1077. ISBN 978-3-88763-075-1.
- ^ Segelman FH, Kelton E, Terzi RM, Kucharczyk N, Sofia RD (June 1985). "The comparative potency of phenobarbital and five 1,3-propanediol dicarbamates for hepatic cytochrome P450 induction in rats". Research Communications in Chemical Pathology and Pharmacology. 48 (3): 467–70. PMID 4023427.
- ^ American Medical Association Dept of Drugs (1977). AMA Drug Evaluations (3rd ed.). Littleton, Mass.: Pub. Sciences Group. p. 406. ISBN 978-0-88416-175-2. OCLC 1024170745.
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