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AT-rich interactive domain-containing protein 3B is a protein that in humans is encoded by the ARID3B gene.[5]
Function
This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000179361 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004661 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: ARID3B AT rich interactive domain 3B (BRIGHT-like)".
Further reading
- Kortschak RD, Tucker PW, Saint R (Jun 2000). "ARID proteins come in from the desert". Trends in Biochemical Sciences. 25 (6): 294–9. doi:10.1016/S0968-0004(00)01597-8. PMID 10838570.
- Numata S, Claudio PP, Dean C, Giordano A, Croce CM (Aug 1999). "Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product". Cancer Research. 59 (15): 3741–7. PMID 10446990.
- Liao TT, Hsu WH, Ho CH, Hwang WL, Lan HY, Lo T, Chang CC, Tai SK, Yang MH (2016). "let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex". Cell Reports. 14 (3): 520–33. doi:10.1016/j.celrep.2015.12.064. PMID 26776511.
External links
- ARID3B+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human ARID3B genome location and ARID3B gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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