Asparagus Officinalis

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Ferrous citrate, also known as iron(II) citrate or iron(2+) citrate, describes coordination complexes containing citrate anions with Fe2+ formed in aqueous solution. Although a number of complexes are possible (or even likely), only one complex has been crystallized. That complex is the coordination polymer with the formula [Fe(H2O)6]2+{[Fe(C6H5O7)(H2O)]−}2.2H2O, where C6H5O73- is HOC(CH2CO2−)2(CO2−, i.e., the triple conjugate base of citric acid wherein the three carboxylic acid groups are ionized.[3] Ferrous citrates are all paramagnetic, reflecting the weak crystal field of the carboxylate ligands.[4]

Structure of the anionic coordination polymer {[Fe(C6H5O7)(H2O)]−}n.[3] (legend: red = O, gray = C, blue = Fe, white = H).

Ferrous citrates are produced by treating disodium citrate Na
2C
6H
6O
7 with sources of iron(II) aquo complexes, such as iron(II) sulfate.[5][2] Ferrous citrates are all highly unstable in air, converting to ferric citrates.

It is a nutrient supplement approved by the FDA.[6][7]

See also

References

  1. ^ Food Chemicals Codex. United States Pharmacopeial Convention. 2010. p. 396. ISBN 978-1-889788-86-9.
  2. ^ a b Perry, Dale L.; Phillips, Sidney L., eds. (1995). Handbook of Inorganic Compounds. Boca Raton, Florida: CRC Press. p. 167. ISBN 0-8493-8671-3.
  3. ^ a b Strouse, Jane; Layten, Steven W.; Strouse, Charles E. (1977). "Structural Studies of transition metal complexes of triionized and tetraionized citrate. Models for the coordination of the citrate ion to transition metal ions in solution and at the active site of aconitase". Journal of the American Chemical Society. 99 (2): 562–572. doi:10.1021/ja00444a041. PMID 830693.
  4. ^ Pierre, J. L.; Gautier-Luneau, I. (2000). "Iron and Citric Acid: A Fuzzy Chemistry of Ubiquitous Biological Relevance". Biometals. 13 (1): 91–96. doi:10.1023/A:1009225701332. PMID 10831230. S2CID 2301450.
  5. ^ "CFR - Code of Federal Regulations Title 21". www.fda.gov. U.S. Food and Drug Administration. 2013-06-01. Retrieved 2014-08-02.
  6. ^ PubChem. "Iron(II) citrate". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-08-22.
  7. ^ "Substances Added to Food (formerly EAFUS)". www.cfsanappsexternal.fda.gov. Retrieved 2022-08-22.


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