Bearberry – Arctostaphylos uva-ursi

by | Dec 10, 2023 | NE Native Shrubs

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AGN-2979 is a glutarimide tryptophan hydroxylase activation inhibitor.[1][2] It shows antidepressant properties in rodent models of depression.[2]

References

  1. ^ Hasegawa S, Kanemaru K, Gittos M, Diksic M (October 2005). "The tryptophan hydroxylase activation inhibitor, AGN-2979, decreases regional 5-HT synthesis in the rat brain measured with alpha-[14C]methyl-L-tryptophan: an autoradiographic study". Brain Research Bulletin. 67 (3): 248–55. doi:10.1016/j.brainresbull.2005.07.009. PMID 16144662. S2CID 41905586.
  2. ^ a b Gittos MW, Papp M (October 2001). "Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats". European Neuropsychopharmacology. 11 (5): 351–7. doi:10.1016/S0924-977X(01)00103-1. PMID 11597821. S2CID 46635727.
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