Allium

by | Mar 21, 2018 | Allium

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2-Chloro-5-hydroxyphenylglycine or CHPG is an agonist of the metabotropic glutamate receptors, specific for mGluR5.[1]

It is capable of directly potentiating the depolarization of hippocampal CA1 neurons induced through NMDA administration.[2]

References

  1. ^ Kammermeier, Paul J (2012). "The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency". BMC Pharmacology. 12: 6. doi:10.1186/1471-2210-12-6. PMC 3416681. PMID 22642439.
  2. ^ Collingridge G.; Volianskis A.; Bannister N.; France G.; Hanna L.; Mercier M.; Tidball P.; Fang G.; Irvine M.; Costa, Blaise M.; Monaghan, Daniel T.; Bortolotto, Zuner A.; Molnár, Elek; Lodge, David; Jane, David E. (2013). "The NMDA receptor as a target for cognitive enhancement". Neuropharmacology. 64: 13–26. doi:10.1016/j.neuropharm.2012.06.051. PMC 4696548. PMID 22796429.


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