Abelia

by | Mar 12, 2018 | Deciduous Shrubs

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Nifurzide is a nitrofuran derivative and intestinal anti-infectious agent active against Escherichia coli.[1]

Synthesis

Esterification of 5-nitrothiophene-2-carboxylic acid (1) with ethanol gives the ester (2). Treatment with hydrazine forms its hydrazide (3). Nifurzide is the hydrazone formed between (3) and 5-nitrofuran-2-acrylaldehyde (4).[2][3][4]

References

  1. ^ Delsarte A, Faway M, Frère JM, Coyette J, Calberg-Bacq CM, Heinen E (March 1981). "Nifurzide, a nitrofuran antiinfectious agent: interaction with Escherichia coli cells". Antimicrobial Agents and Chemotherapy. 19 (3): 477–86. doi:10.1128/aac.19.3.477. PMC 181457. PMID 7018391.
  2. ^ US patent 3847911, Szarvasi E, Fontaine L, "Novel substituted(nitrofurylacrylidene)hydrazines with antibacterial properties", issued 1974-11-12 
  3. ^ Szarvasi E, Fontaine L, Betbeder-Matibet A (March 1973). "Antimicrobials. New nitrofuran derivatives". Journal of Medicinal Chemistry. 16 (3): 281–287. doi:10.1021/jm00261a027. PMID 4200221.
  4. ^ "Nifurzide". Pharmaceutical Substances. Thieme. Retrieved 2024-07-02.
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